Jie Fan, Ph.D.

Assistant Professor of Biology
College of Arts, Sciences, and Letters
Natural Sciences

Teaching Areas:

Biological Sciences

Research Areas:

Bioengineering, Cell biology

Biography and Education

Jie Fan joined the University of Michigan-Dearborn in fall 2020. His study on endothelial cell chirality (handedness) firstly demonstrated that cell chirality is closely related to tissue/organ functions in a human body. His lab focuses on exploring the roles of cell chirality in various aspects related to human health, including heart beating, blood vessel permeability, cancer development, and neurodegeneration. The ultimate endeavor of his lab is to develop novel preventive and therapeutic strategies for human diseases by utilizing the chiral property of cells.

Education and Training
  • Postdoctoral training: Rensselaer Polytechnic Institute; City University of New York - City College
  • Ph.D.: Beihang University
  • B.S.: Sichuan University

Selected Publications

Cell organelle-based analysis of cell chirality. J Fan, H Zhang, T Rahman, DN Stanton, LQ Wan. Commun. Integr. Biol. 2019

Cell chirality regulates intercellular junctions and endothelial permeability. J Fan, P Ray, YW Lu, G Kaur, JJ Schwarz, LQ Wan. Sci. Adv. 2018

Intrinsic cellular chirality regulates left-right symmetry breaking during cardiac looping. P Ray, AS Chin, KE Worley, J Fan, G Kaur, M Wu, LQ Wan. PNAS. 2018

Epithelial cell chirality revealed by three-dimensional spontaneous rotation. AS Chin, KE Worley, P Ray, G Kaur, J Fan, LQ Wan. PNAS. 2018

Quantification of malignant breast cancer cell MDA-MB-231 transmigration across brain and lung microvascular endothelium. J. Fan, B.M. Fu. Ann. Biomed. Eng. 2016